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Abstract #3879

Minimum echo-time PRESS-localized proton observed carbon edited (POCE) magnetic resonance spectroscopy for rat brain imaging using simultaneous editing and localization pulses.

Chathura Kumaragamage1, Dan Madularu2, Axel P Mathieu3, Derek Lupinsky3, Robin A de Graaf4, and Jamie Near2

1Biomedical Engineering, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3Douglas Hospital Brain Imaging Center, Montreal, QC, Canada, 4Yale University, New Haven, CT, United States

Dynamic Carbon-13 (13C) magnetic resonance spectroscopy (MRS) remains to be the only noninvasive method capable of measuring neuroenergetics and neurotransmitter cycling in the brain1. Proton observed carbon edited (POCE) MRS2 is an attractive alternative to direct 13C methods due to improved signal-to-noise-ratio (SNR). This study reports a PRESS localized POCE sequence utilizing simultaneous editing and localization (SEAL-PRESS), which allows the TE to be reduced to a theoretically optimal value of ~1/JHC (8.1ms, in this implementation). The sequence was validated in phantom and in a rat preparation, and demonstrated >17% improvement in 13C labeled metabolites relative to a 12.6-ms PRESS-POCE sequence.

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