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Abstract #3881

Coil Combination Methods for 16-channel Hyperpolarized 13C Spectroscopic Imaging Studies of Liver Metastases Patients

Zihan Zhu1,2, Xucheng Zhu1,2, Michael Ohliger1, Peng Cao1, Shuyu Tang1,2, Jeremy W Gordon1, Lucas Carvajal1, Peter J Shin1, Rahul Aggarwal3, Robert Bok1, John Kurhanewicz1, Pamela Munster3, Peder E.Z. Larson1, and Daniel B Vigneron1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley - UCSF Graduate Program in Bioengineering, UCSF, San Francisco, CA, United States, 3Department of Medicine, UCSF, San Francisco, CA, United States

Effective coil combination methods for human hyperpolarized 13C spectroscopy data remain relatively unexplored. This study implemented several coil combination methods, including sum-of-squares (SOS), singular value decomposition (SVD), and pyruvate map based sensitivity calibration (PyrMap). These methods were evaluated by both simulation and in human cancer studies. Overall, both the SVD and PyrMap methods demonstrated better accuracy and robustness than SOS, and the PyrMap best preserved the phase information.

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