Abstract #3881

Coil Combination Methods for 16-channel Hyperpolarized 13C Spectroscopic Imaging Studies of Liver Metastases Patients

Zihan Zhu^1,2, Xucheng Zhu^1,2, Michael Ohliger¹, Peng Cao¹, Shuyu Tang^1,2, Jeremy W Gordon¹, Lucas Carvajal¹, Peter J Shin¹, Rahul Aggarwal³, Robert Bok¹, John Kurhanewicz¹, Pamela Munster³, Peder E.Z. Larson¹, and Daniel B Vigneron¹

¹Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²UC Berkeley - UCSF Graduate Program in Bioengineering, UCSF, San Francisco, CA, United States, ³Department of Medicine, UCSF, San Francisco, CA, United States

Effective coil combination methods for human hyperpolarized ¹³C spectroscopy data remain relatively unexplored. This study implemented several coil combination methods, including sum-of-squares (SOS), singular value decomposition (SVD), and pyruvate map based sensitivity calibration (PyrMap). These methods were evaluated by both simulation and in human cancer studies. Overall, both the SVD and PyrMap methods demonstrated better accuracy and robustness than SOS, and the PyrMap best preserved the phase information.

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