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Abstract #3882

The effects of iodinated CT contrast agent on phosphorus MRS

Ladislav Valkovic1,2, Justin YC Lau1,3, Ines Abdesselam1, Oliver Rider1, Damian J Tyler1,3, Christopher T Rodgers1,4, and Jack JJJ Miller1,3,5

1Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sceinces, Bratislava, Slovakia, 3Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 4The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 5Department of Physics, University of Oxford, Oxford, United Kingdom

Contrast-enhanced CT examination can influence 1H-MRI measurements performed within 24h after the CT scan, due to a reduction in water T1 and T2 caused by the iodinated contrast agents used in CT. We have investigated whether contrast from a previous CT examination would also influence metabolic measurements made using 31P-MRS, by measuring the T1 of 1H and 31P signals in human blood. We find that iodinated CT contrast agent has no effect on phosphorus T1s. Therefore, 31P-MRS examinations will not be influenced by prior CT (unlike 1H-MRI scans).

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