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Abstract #3883

In vivo 31P MRI at 7 Tesla in humans using a 3D spectrally selective SSFP sequence and TPI k-space sampling.

Arthur Coste1, Sandro Romanzetti2, Denis Le Bihan1, Cécile Rabrait-Lerman1, and Fawzi Boumezbeur1

1DRF-ISVFJ-NeuroSpin, CEA, Paris Saclay University, Gif sur Yvette, France, 2Neurology Department, RWTH Aachen University Hospital, Aachen, Germany

Spectrally selective 31P MRI can be of interest for the study of brain energetics for clinical research. Using a 3D SSFP sequence with non-Cartesian Twisted Projection Imaging sampling, we obtained whole-brain images of ATP and PCr in healthy volunteers at 7 Tesla with a higher normalized SNR than with CSI. Local concentration quantification was performed using the phantom replacement approach after accounting for the T1/T2-weighting and the transmission and reception profiles of our coil yielding consistent results.

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