Huntington’s disease is a genetic neurodegenerative disorder caused by the abnormal repetition of the CAG triplet in the gene coding for huntingtin (Htt). R6/1 mouse model, expressing a human form of mutated huntingtin, exhibits a progressive neuronal alteration in the striatum. We use in vivo MRS and diffusion-weighted MRS at various diffusion-weightings and diffusion times to detect changes in cellular metabolic content and structure R6/1 mice striatum. We report massive metabolic remodeling, especially for N-acetyl aspartate (NAA) and Glutamine (Gln), as well as changes in glutamate diffusion properties that we tentatively relate to variations in glutamate cellular compartmentation.
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