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Abstract #3888

Probing alterations of cellular metabolism in a mouse model of Huntington’s disease (R6/1) using in vivo MRS and DW-MRS

Clémence Ligneul1, Edwin Hernandez-Garzon1, Marco Palombo2, Julien Flament1,3, and Julien Valette1

1Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique (CEA), Fontenay aux Roses, France, 2UCL, London, United Kingdom, 3UMS 27, INSERM, Fontenay aux Roses, France

Huntington’s disease is a genetic neurodegenerative disorder caused by the abnormal repetition of the CAG triplet in the gene coding for huntingtin (Htt). R6/1 mouse model, expressing a human form of mutated huntingtin, exhibits a progressive neuronal alteration in the striatum. We use in vivo MRS and diffusion-weighted MRS at various diffusion-weightings and diffusion times to detect changes in cellular metabolic content and structure R6/1 mice striatum. We report massive metabolic remodeling, especially for N-acetyl aspartate (NAA) and Glutamine (Gln), as well as changes in glutamate diffusion properties that we tentatively relate to variations in glutamate cellular compartmentation.

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