Meeting Banner
Abstract #3889

Metabolite concentration changes associated with positive and negative BOLD signal in the human visual cortex: a functional magnetic resonance spectroscopy study at 7T.

Yohan Boillat1, Lijing Xin2, Wietske Van der Zwaag2,3, and Rolf Gruetter1,2,4,5

1LIFMET, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2CIBM, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 4Department of Radiology, University of Geneva, Geneva, Switzerland, 5Department of Radiology, University of Lausanne, Lausanne, Switzerland

The metabolite correlates of the negative BOLD signal were investigated using functional MRS and compared to the changes produced by the positive BOLD response. The participants were scanned in a 7-T MRI while passively viewing visual checkerboards. For the positive BOLD response, increases of glutamate and lactate concentrations were observed, while the negative BOLD response in a similar voxel was linked to a decrease of glutamate, lactate and GABA concentrations. This measured decrease of oxidative metabolism during the negative BOLD response suggest a reduction a glutamatergic activity in the visual cortex.

This abstract and the presentation materials are available to members only; a login is required.

Join Here