Abstract #3897

Energy Metabolism Differences in Rat Skeletal Muscle Due to Restricted Ambulation Following SCI

Celine Baligand¹, Fan Ye², Sean C Forbes³, Ravneet S Vohra¹, Jonathon Keener⁴, Prodip Bose⁴, Floyd Thompson⁴, Glenn A Walter¹, and Krista Vandenborne³

¹Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States, ²Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States, ³Physical Therapy, University of Florida, Gainesville, FL, United States, ⁴Physiological Sciences, University of Florida, Gainesville, FL, United States

Classic rodent models of SCI can rapidly and spontaneously recover locomotor function, muscle mass, and energy metabolism within weeks after injury. This is attributed to “self training” and does not replicate the conditions experienced by human patients who are often confined to bed rest for an extended period of time. Using ³¹P-MRS during electrically stimulated exercise to assess mitochondrial oxidative capacity in vivo, we show that restricted activity by cast immobilization delays spontaneous recovery of skeletal muscle metabolism in a rat model of severe SCI.

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