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Abstract #3898

Noninvasive biomarkers for the early diagnosis and staging of hepatic fibrosis : A real-time in vivo hyperpolarized 13C MR spectroscopy

Chung-Man Moon1, Yong-Yeon Jeong2, Il-Woo Park2, and Sang-Soo Shin2

1Advanced Institute of Aging Science, Chonnam National University, Gwangju, Republic of Korea, 2Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea

Hepatic fibrosis associated with chronic liver injury can progress to cirrhosis and ultimately hepatocellular carcinoma. To date, liver biopsy has been regarded as the gold standard for detecting hepatic fibrosis but with practical constraints. Therefore, alternative non-invasive diagnostic methods that can precisely evaluate progression of hepatic fibrosis are urgently needed. However, an in vivo study for hepatic fibrosis using hyperpolarized 13C-labeled pyruvate has not yet been attempted until now. The purpose of this study was to investigate the cellular metabolic changes at different stages of hepatic fibrosis for the early diagnosis.

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