Abstract #3904

Relationship of longitudinal changes in cerebral metabolite and diffusivity property during the early brain development

Chun-Xia Li¹, Yuguang Meng¹, Hui Mao², Anthony WS Chan^3,4, and Xiaodong Zhang^1,5

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Radiology and imaging science, Emory University, Atlanta, GA, United States, ³Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, GA, United States, ⁴Divisions of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ⁵Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate, Emory University, Atlanta, GA, United States

In vivo Magnetic Resonance Spectroscopy (MRS) is widely used to characterize the cerebral metabolic disorders in the developing brains of human and animal models. Prior study has demonstrated the spatial and temporal difference in evolution pattern of each metabolite during early brain maturation. This study is aimed to investigate the relationship of the longitudinal change of each metabolite with the microstructural evolution during early brain development in the cingulate cortex (ACC) of rhesus monkeys. The results demonstrated the heterogeneity of correlation degree of each metabolite with the microstructural maturation, suggesting combined MRS/DTI examination could offer complementary information to characterize early brain maturation and related disorders in pediatric research.

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