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Abstract #3905

Higher Vitamin C Concentration in Patients with Alzheimer’s Disease

Malgorzata Marjanska1, J Riley McCarten1,2, Laura Hemmy1,2, and Melissa Terpstra1

1University of Minnesota, Minneapolis, MN, United States, 2VA Health Care System, Minneapolis, MN, United States

The concentrations of the antioxidants vitamin C (ascorbate, Asc) and glutathione (GSH) were quantified as components of the neurochemical profile using 7 T 1H MRS in patients with Alzheimer’s disease (AD) and age-matched controls. Spectra were measured at ultra-short echo time in the posterior cingulate cortex (PCC), which is involved in AD, and the occipital cortex (OCC) as a control region. In patients, the concentrations of Asc and myo-inositol were higher in both regions. In the PCC of patients, total choline concentration was also higher.

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