Meeting Banner
Abstract #3912

Synthetic MRI of bone metastases in castration-resistant prostate cancer: detection of tumor activity and calcifications.

Yuki Arita1,2, Taro Takahara3, Soichiro Yoshida4, Thomas C Kwee5, Tatsuaki Kobayashi6, Chikako Ishii7, Jun Kurasawa7, Kazuya Sugimoto3, Nobuya Higuchi1,2, and Yasuhisa Fujii4

1Department of Radiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan, 2Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan, 3Department of Biomedical Engineering, Tokai University School of Engineering, Kanagawa, Japan, 4Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan, 5Department of Radiology, UMC Groningen, Groningen, Netherlands, 6Visionary Imaging Services, Inc., Yokohama, Japan, 7Department of Radiology, Advanced Imaging Center Yaesu Clinic, Tokyo, Japan

We quantified T1, T2, and proton density (PD) of bone metastases in castration-resistant prostate cancer with synthetic MRI (SyMRI). Bone foci of interest were classified into four groups; active disease, red bone marrow (RBM), inactive disease without calcification (Inactive C(-)), and inactive disease with calcification (Inactive C(+)). Active disease group showed very high PD, and Inactive C(+) group showed very low PD. Both Inactive C(-) and RBM showed medium values. Significant differences were noted among these three divisions. SyMRI thus shows clinical potential to differentiate active/inactive lesions, calcifications, and red bone marrow in castration-resistant prostate cancer.

This abstract and the presentation materials are available to members only; a login is required.

Join Here