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Abstract #3913

Hyperpolarized [1-13C]Pyruvate Imaging Predicts Survival in Rat C6 Glioma Model

Keshav Datta1, Mette H. Lauritzen1, Milton Merchant2, Taichang Jang2, Shie-Chau Liu1, Ronald D. Watkins 1, Ralph E. Hurd1, Lawrence Recht2, and Daniel M. Spielman1

1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Neurology, Stanford University, Stanford, CA, United States

The [1-13C]Lactate/[1-13C]Bicarbonate ratio at 48 hrs post-treatment, as measured in a hyperpolarized [1-13C]Pyruvate experiment, was found to accurately predict the survival in rat C6 glioma model treated with a single dose of the anti-VEGF drug Bevacizumab.

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