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Abstract #3917

Correlation of CD31-Based Microvessel Density and Percent Area Measurements against 13C-tert-butanol MRI Perfusion Mapping in a Sunitinib-Resistant RCC Xenograft

Patricia Coutinho de Souza1, Aaron Grant1, Xiaoen Wang1, Rupal Bhatt2, Gopal Varma1, David Alsop1, and Leo Tsai1

1Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 2Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States

Tumor heterogeneity is deeply associated with regional perfusion. Improved evaluation of local perfusion, by imaging or histology, can be useful for tracking tumor progression and treatment. Here we use h13C-tert-butanol, a high-SNR quantitative MRI perfusion marker, to map perfusion in untreated (UT) and sunitinib-resistant (SR) renal cell carcinoma (RCC) xenografts. This study investigates the correlation between these perfusion maps with histologic measures of vascularity using CD31-labeled sections.

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