Abstract #3917

Correlation of CD31-Based Microvessel Density and Percent Area Measurements against 13C-tert-butanol MRI Perfusion Mapping in a Sunitinib-Resistant RCC Xenograft

Patricia Coutinho de Souza¹, Aaron Grant¹, Xiaoen Wang¹, Rupal Bhatt², Gopal Varma¹, David Alsop¹, and Leo Tsai¹

¹Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States, ²Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States

Tumor heterogeneity is deeply associated with regional perfusion. Improved evaluation of local perfusion, by imaging or histology, can be useful for tracking tumor progression and treatment. Here we use h13C-tert-butanol, a high-SNR quantitative MRI perfusion marker, to map perfusion in untreated (UT) and sunitinib-resistant (SR) renal cell carcinoma (RCC) xenografts. This study investigates the correlation between these perfusion maps with histologic measures of vascularity using CD31-labeled sections.

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