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Abstract #3946

CEST MRI of 3-O-Methyl-D-Glucose uptake and accumulation in brain tumors

Akansha Ashvani Sehgal1,2, Yuguo Li1,2, Bachchu Lal3, Nirbhay N Yadav1,2, Xiang Xu1,2, Jiadi Xu1,2, John Laterra3, and Peter C. M van Zijl1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Neurology, Oncology, and Neuroscience, The Johns Hopkins Medicine, and The Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, United States

Glucose weighted chemical exchange saturation transfer (CEST) imaging has garnered a lot of interest in the past few years as it can be a safe alternative to gadolinium contrast based MRI for tumor diagnosis. 3-O-methyl glucose (3-OMG) is a structural analog of glucose which, because of its apparent non-toxicity and its property to not get metabolized, has been shown to be another promising CEST contrast agent. Here we explore its application as a CEST contrast agent for assessing brain tumors.

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