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Abstract #3947

Bio-orthogonal MR imaging – A novel method proposed for metastatic cancer detection

Tanner Ravsten1, William Pitt1, Neal Bangerter2, Randy Hartley2, Forrest Howell2, and Jessica Doud2

1Chemical Engineering, Brigham Young University, Provo, UT, United States, 2Electrical Engineering, Brigham Young University, Provo, UT, United States

Metastatic tumors (METs) cause 90% of cancer deaths since their small size makes detection difficult. A bio-orthogonal method is demonstrated where two distinct detection molecules and mechanisms are employed with minimal interference. Gadolinium (Gd) and Iron-Oxide-Particles (IOP) with respective MRI T1 and T2* scans were hypothesized to produce orthogonality in the resulting images. In vitro experiments showed respective minimum detectability limits of Gd and IOP at 1µL, 0.25µM and 0.5µL, 6µM. Ex vivo experiments demonstrated Gd and IOP detection at 0.313-0.625mM. Thus the plausibility of bio-orthogonal MET detection to reduce the likelihood of false positive and negative diagnoses is very high.

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