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Abstract #3948

A 3D Spiral/Radial sequence for both anatomical and DCE imaging of pulmonary metastases in mice

Emeline Julie RIBOT1, Charles Castets1, Wilfried Souleyreau2, Lin Cooley2, Andreas Bikfalvi2, Aurélien Trotier1, and Sylvain Miraux1

1CRMSB UMR5536, CNRS-Univ.Bordeaux, Bordeaux, France, 2LAMC U1029, INSERM, Talence, France

In order to detect and characterize pulmonary metastases in small animals, a 3D UTE sequence using a hybrid radial/spiral encoding, was employed while free breathing. Due to the high contrast and the high spatial resolution (125μm isotropic), early-growing metastases (representing less than 10 voxels) were detected in mice in only 12min. In parallel, through the acceleration of the acquisition by 4, the same sequence was used to perform, for the 1st time, DCE-MRI on pulmonary metastases in mice. The new pulmonary-dedicated sequence enables to obtain either anatomical or DCE-MRI information in mice.

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