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Abstract #3949

Correlation of Native Liver T1 mapping to post contrast T1 mapping, Apparent Diffusion Coefficient (ADC) and Dynamic Contrast Enhancement (DCE) Maps in a Rabbit Model for Liver Cancer

Dana C Peters1, Daniel Coman1, Julius Chapiro1, John Walsh1, Fahmeed Hyder1, Tsa Shelton2, Johanna van Breugel1, Tabea Borde1, Lynn Savic1, MingDe Lin1,3, Albert J Sinusas2, Jean-Francois Geschwind4, Douglas Rothman1, R. Todd Constable1, James S Duncan1, and Steffen Huber1

1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Medicine, Yale University, New Haven, CT, United States, 3U/S Imaging and Interventions, Philips Research North America, Cambridge, MA, United States, 4PreScience Labs, Westport, CT, United States

We investigated native T1 mapping for detection of liver tumors in comparison to multi-parametric MRI. In 13 rabbits with implanted 2 week VX2 tumor, 9 of which underwent transarterial chemoembolization (TACE), native T1 mapping showed a similar spatial pattern compared to dynamic contrast enhanced (DCE) imaging, apparent diffusion coefficient maps (ADC), and post-contrast T1 maps. Native T1 is highest in central necrosis, intermediate in viable hypervascular tumor, and lowest in normal liver.

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