Abstract #3949

Correlation of Native Liver T1 mapping to post contrast T1 mapping, Apparent Diffusion Coefficient (ADC) and Dynamic Contrast Enhancement (DCE) Maps in a Rabbit Model for Liver Cancer

Dana C Peters¹, Daniel Coman¹, Julius Chapiro¹, John Walsh¹, Fahmeed Hyder¹, Tsa Shelton², Johanna van Breugel¹, Tabea Borde¹, Lynn Savic¹, MingDe Lin^1,3, Albert J Sinusas², Jean-Francois Geschwind⁴, Douglas Rothman¹, R. Todd Constable¹, James S Duncan¹, and Steffen Huber¹

¹Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Medicine, Yale University, New Haven, CT, United States, ³U/S Imaging and Interventions, Philips Research North America, Cambridge, MA, United States, ⁴PreScience Labs, Westport, CT, United States

We investigated native T1 mapping for detection of liver tumors in comparison to multi-parametric MRI. In 13 rabbits with implanted 2 week VX2 tumor, 9 of which underwent transarterial chemoembolization (TACE), native T1 mapping showed a similar spatial pattern compared to dynamic contrast enhanced (DCE) imaging, apparent diffusion coefficient maps (ADC), and post-contrast T1 maps. Native T1 is highest in central necrosis, intermediate in viable hypervascular tumor, and lowest in normal liver.

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