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Abstract #3956

Hypoxia in Rat Prostate Tumors: Correlation of BOLD/TOLD MRI with [18F]FMISO PET

Heling Zhou1, Srinivas Chiguru1, Rami Hallac1,2, Donghan M Yang1, Guiyang Hao1, Peter Peschke3, and Ralph P Mason1

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2AIM Center, Children's Health, Dallas, TX, United States, 3Clinical Cooperation, German Cancer Research Center, Heidelberg, Germany

18F-fluoromisonidazole ([18F]FMISO) has been exploited in positron emission tomography (PET) as an imaging radiotracer for tumor hypoxia. The accumulation of [18F]FMISO must depend on both hypoxia and perfusion. In this study, we investigated [18F]FMISO activity in the AT1 tumor rat model and found that [18F]FMISO produced conflicting results in the poorly perfused hypoxic tumors. The preliminary results indicate that BOLD and TOLD MRI can provide complimentary information for interpretation of the [18F]FMISO results.

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