Abstract #3956

Hypoxia in Rat Prostate Tumors: Correlation of BOLD/TOLD MRI with [18F]FMISO PET

Heling Zhou¹, Srinivas Chiguru¹, Rami Hallac^1,2, Donghan M Yang¹, Guiyang Hao¹, Peter Peschke³, and Ralph P Mason¹

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²AIM Center, Children's Health, Dallas, TX, United States, ³Clinical Cooperation, German Cancer Research Center, Heidelberg, Germany

¹⁸F-fluoromisonidazole ([¹⁸F]FMISO) has been exploited in positron emission tomography (PET) as an imaging radiotracer for tumor hypoxia. The accumulation of [¹⁸F]FMISO must depend on both hypoxia and perfusion. In this study, we investigated [¹⁸F]FMISO activity in the AT1 tumor rat model and found that [¹⁸F]FMISO produced conflicting results in the poorly perfused hypoxic tumors. The preliminary results indicate that BOLD and TOLD MRI can provide complimentary information for interpretation of the [¹⁸F]FMISO results.

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