Abstract #3957

Assessment of tumors aggressiveness in papillary thyroid cancer (PTC) using DCE-MRI

Ramesh Paudyal¹, Yonggang Lu², Vaios Hatzoglou³, David Aramburu Nunez¹, Andre Moreira⁴, Yousef Mazaheri^1,3, Mithat Gonen⁵, Joseph O. Deasy¹, Ashok Shaha⁶, R. Michael Tuttle⁷, and Amita Shukla-Dave^1,3

¹Medical Physcis, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ³Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁴Pathology, NYU Langone Medical Center, New York, NY, United States, ⁵Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁶Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁷Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States

In this study, pretreatment dynamic contrast enhanced (DCE-MRI) data was analyzed using the Tofts model (TM), extended Tofts model (ETM), and two compartment exchange model (2CXM) to quantify perfusion-related quantitaive imaging metrics in papillary thyroid cancer (PTC) patients. The histopathological features of aggressiveness were used as the standard of reference. The results indicated that the ETM provided better fit among the models. The ETM Ktrans values were able to distinguish between aggressive and non-aggressive tumors. The study concludes that pretreatment perfusion-related metric can be useful biomarkers for stratifying tumor aggressiveness in PTC patients.

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