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Abstract #3959

Simultaneous Measurement of Glutamate, Glutamine, GABA, and Glutathione by Spectral Editing Without Subtraction

Li An1 and Jun Shen1

1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

A novel spectral editing approach was proposed to simultaneously measure glutamate, glutamine, GABA, and glutathione at 7 T. By using a single editing pulse, a relatively short echo time of 56 ms was achieved. The main targets of the signal detection were the H2 and H4 protons of GABA and the H4 protons of glutamate, glutamine, and the glutamyl moiety of glutathione. No motion-sensitive data subtraction was required.

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