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Abstract #3960

High-Speed Density Matrix Simulation of PRESS with A Single Editing Pulse

Li An1 and Jun Shen1

1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

A single spectral editing pulse incorporated into the PRESS sequence produces large Bloch-Siegert shift. The lack of a general method to quantify these shifts for spectral editing experiments has made it necessary to use a second identical editing pulse to cancel the shift. Here we describe a high-speed density matrix simulation method to accurately simulate a PRESS sequence with a single editing pulse for simultaneous detection of glutamate, glutamine, GABA, and glutathione at TE = 56 ms and 7 Tesla. To facilitate in vivo quantification, the frequency dependent Bloch-Siegert shift is accurately calculated and removed from the spectra.

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