γ-aminobutyric acid (GABA) and glutathione (GSH) can be simultaneously measured in the human brain in vivo at 3T using Hadamard encoding and reconstruction of MEGA-edited spectroscopy (HERMES). A drawback of conventional HERMES of GABA/GSH is the contamination of the edited GABA peak with co-edited macromolecular signals (MM), reducing the specificity of the method. We propose the addition of symmetrical suppression into the HERMES framework, and demonstrate the successful implementation of this approach in ten healthy subjects.
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