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Abstract #3964

Test-retest reproducibility of quantitative proton MRS using short-TE STEAM and semi-LASER sequences in young adult volunteer brains at 7T.

Tomohisa Okada1, Hideto Kuribayashi2, Lana G Kaiser2, Yuta Urushibata2, Nouha Salibi3, Ravi Teja Seethamraju3, Sinyeob Ahn3, Tadashi Isa1, and Koji Fujimoto1

1Kyoto University, Kyoto, Japan, 2Siemens Healthcare K.K., Tokyo, Japan, 3Siemens Healthcare, USA, Malvern, PA, United States

Recently, 7T-MR system has been approved for clinical use in Europe and USA; however, its clinical configuration is limited to single-channel transmit so B1+ shimming is not feasible. This study investigated reproducibility of single-voxel MRS using short-TE STEAM and semi-LASER using a single-transmit & 32-receiver head coil at 7T. Fifteen healthy young volunteers were scanned twice at the posterior cingulate. SNR was higher in semi-LASER, but coefficients of variation were comparable ranging mainly from 5-10% and better in short-TE STEAM in low-concentration J-coupled peaks. Even with clinical setups, 7T shows high reliability and will contribute to MRS investigation.

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