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Abstract #3963

Bilateral functional MRS of GABA with real-time frequency and motion correction at 7T

Anouk Marsman1, Vincent Oltman Boer1, Mads Andersen2, and Esben Thade Petersen1,3

1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Philips, Copenhagen, Denmark, 3Center for Magnetic Resonance, Dept. Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

Brain function is largely controlled by inhibitory processes steered by main inhibitory neurotransmitter GABA. In this role, GABA is essential in brain development and plasticity as well as neuropsychiatric and neurodegenerative diseases. In order to accurately measure GABA responsiveness, we designed a bilateral edited fMRS sequence including real-time frequency and motion correction, as the relatively weak GABA signal is highly susceptible to frequency drift and motion. As acquisition of the macromolecule-uncontaminated GABA signal is challenging at lower field strengths, experiments were performed at 7T.

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