Brain function is largely controlled by inhibitory processes steered by main inhibitory neurotransmitter GABA. In this role, GABA is essential in brain development and plasticity as well as neuropsychiatric and neurodegenerative diseases. In order to accurately measure GABA responsiveness, we designed a bilateral edited fMRS sequence including real-time frequency and motion correction, as the relatively weak GABA signal is highly susceptible to frequency drift and motion. As acquisition of the macromolecule-uncontaminated GABA signal is challenging at lower field strengths, experiments were performed at 7T.
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