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Abstract #3966

Non-water Suppressed GABA Edited Magnetic Resonance Spectroscopic Imaging using Density Weighted Concentric Rings k-space Trajectory

Uzay E Emir1, Pingyu Xia1, Xiaopeng Zhou1, Mark Chiew2, Adam Steel3,4, M Albert Thomas5, and Ulrike Dydak1,6

1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 4National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 5Department of Radiological Sciences, University of California, Los Angeles, CA, United States, 6Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

In this study, we have developed and demonstrated a non-water suppressed GABA editing Magnetic Resonance Spectroscopic Imaging technique using density-weighted concentric rings k-space trajectory that performs robustly within a clinically feasible acquisition time at 3T. The method has been validated in a series of phantom experiments and its feasibility assessed in a healthy volunteer with a high in-plane resolution of 7.5 × 7.5 mm2. Experiments qualitatively demonstrate the advantage of the proposed method in terms of its improved resolution and reduced contamination of spectra from neighboring voxels.

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