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Abstract #3967

Automated MR Spectrum Registration for In Vivo Mouse MEGA-PRESS Study at 9.4T And the Introduction of MRSMouse2.0

Jia Guo1, Douglas L. Rothman2, and Scott A. Small3

1Department of Biomedical Engineering, Columbia University, New York, NY, United States, 2Biomedical Engineering & Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 3Departments of Neurology, Radiology or Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, United States

The goal of this study was to develop the tailored automated processing and quantification software for Meshcher–Garwood point resolved spectroscopy (MEGA-PRESS) in research of mouse models at 9.4T. The proposed software, MRSMouse, consists of two modules: the data loading module, MRSMouseLoad, which reads the Bruker time-domain raw data and processes it into a frequency-domain GABA-edited spectrum with bandwidth, frequency and phase drift correction through spectrum registration; and the spectral fitting module, MRSMouseFit, which quantifies the metabolite concentrations by modeling the spectra as a linear combination of the simulated basis-set and a smooth-spline in the frequency domain.

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