Abstract #3971

Spectral simulations of glutathione at 7T: Comparison of two different spin system parameter sets

Muhammad Gulamabbas Saleh^1,2, Mark Mikkelsen^1,2, Georg Oeltzschner^1,2, Kimberly L. Chan^1,2,3, Adam Berrington^1,2, Peter B. Barker^1,2, and Richard A. E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Glutathione (GSH) is a redox compound, providing protection against reactive oxygen species. Abnormal variation in GSH concentration has been associated with several neurological diseases. Several studies quantify low-concentration metabolites, such as GSH, using simulated basis sets derived from spin system parameters available in the literature. Through simulations and phantom experiments, we assess the accuracy of two different sets of spin system parameters of GSH-cysteine at 7T. The disagreement between the phantom and simulation GSH-cysteine spectra suggests a need for further refinement of the spin system parameters.

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