Abstract #3972

Simultaneous editing of GABA and glutathione at 7T

Muhammad Gulamabbas Saleh^1,2, Mark Mikkelsen^1,2, Georg Oeltzschner^1,2, Kimberly L. Chan^1,2,3, Adam Berrington^1,2, Peter B. Barker^1,2, and Richard A. E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

HERMES has been shown to simultaneously edit GABA and GSH at 3T. Spectral editing at 7T provides better editing pulse selectivity, e.g. quantifying GABA with less contamination from macromolecules. In this abstract, simulations, phantom and in vivo experiments were performed at 7T using the sLASER sequence for simultaneous editing of GABA and GSH using HERMES. HERMES with sLASER localization at 7T provides uniform localization, doubles the acquisition rate, and provides excellent separation of the metabolites without any loss in spectral quality compared to sequentially acquired measurements of GABA and GSH using MEGA-PRESS.

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