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Abstract #3974

Multi-Step Frequency-and-Phase Correction for Multiplexed Edited MRS Data

Mark Mikkelsen1,2, Muhammad G. Saleh1,2, Jamie Near3, Kimberly L. Chan1,2,4, Tao Gong5, Ashley D. Harris6, Georg Oeltzschner1,2, Nicolaas A. J. Puts1,2, Kim M. Cecil7, Iain D. Wilkinson8, and Richard A. E. Edden1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, 4Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 6Department of Radiology, University of Calgary, Calgary, AB, Canada, 7Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 8Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Multiplexed edited MRS – more than one edited experiment combined in a single acquisition – involves acquiring subspectra with four or more distinct signal profiles. This technique therefore requires a tailored approach for correcting frequency and phase errors associated with participant head motion and scanner instability. Here, we demonstrate a novel alignment algorithm, termed multi-step frequency-and-phase correction (msFPC), designed to deal with the challenges of aligning individual transients in multiplexed edited data. Testing this method on simulated and in vivo datasets, msFPC was found to outperform other previously demonstrated algorithms (spectral registration and spectral registration with post hoc choline-creatine alignment).

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