Abstract #3975

Scan Duration, Signal-To-Noise Ratio and Sample Size Considerations in GABA-Edited MRS Studies

Mark Mikkelsen^1,2, Rachelle S. Loo^3,4, Nicolaas A. J. Puts^1,2, Richard A. E. Edden^1,2, and Ashley D. Harris^3,4

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁴CAIR Program, Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

We investigate the relationships between scan duration, signal-to-noise ratio (SNR) and group-level variance in GABA-edited MRS. Typically, GABA editing takes ~10 min for a 27-mL voxel. GABA+/Cr measurements from five voxels from 18 participants were analyzed by cumulatively binning the averages within each dataset to determine the effects on SNR and group-level variance. Sample size calculations estimated the required sample sizes needed for different predicted effect sizes in GABA-edited MRS studies. We show that the duration of GABA-edited acquisitions can be reduced if taking into account a statistically acceptable amount of group-level variance and the magnitudes of predicted effects.

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