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Abstract #3975

Scan Duration, Signal-To-Noise Ratio and Sample Size Considerations in GABA-Edited MRS Studies

Mark Mikkelsen1,2, Rachelle S. Loo3,4, Nicolaas A. J. Puts1,2, Richard A. E. Edden1,2, and Ashley D. Harris3,4

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, University of Calgary, Calgary, AB, Canada, 4CAIR Program, Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

We investigate the relationships between scan duration, signal-to-noise ratio (SNR) and group-level variance in GABA-edited MRS. Typically, GABA editing takes ~10 min for a 27-mL voxel. GABA+/Cr measurements from five voxels from 18 participants were analyzed by cumulatively binning the averages within each dataset to determine the effects on SNR and group-level variance. Sample size calculations estimated the required sample sizes needed for different predicted effect sizes in GABA-edited MRS studies. We show that the duration of GABA-edited acquisitions can be reduced if taking into account a statistically acceptable amount of group-level variance and the magnitudes of predicted effects.

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