B0-inhomogeneity-insensitive GABA editing with MM suppression has been developed using improved MEGA-SPECIAL sequence using highly selective (30 ms) editing pulses allowed by 1D ISIS localization and 1D echo planar gradient in the logical S/I direction. MM suppressed GABA editing was successfully achieved in occipital lobe. However, GABA editing in regions near sinuses, e.g. anterior cingulate cortex (ACC), was compromised from imperfect subtraction in the ISIS localization. To reduce artifact in this region, the ISIS and 1D EP gradient were applied in the logical R/L direction together with a 16-step phase-cycled acquisition. These methods significantly improved edited spectra obtained from ACC.
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