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Abstract #3979

Macromolecule Suppressed GABA Editing with Reduced Artifact in Region near Sinuses using Improved MEGA-SPECIAL Sequence

Meng Gu1, Ralph Hurd1, Laima Baltusis2, Frederick T. Chin1, and Daniel M. Spielman1

1Radiology, Stanford University, Stanford, CA, United States, 2Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA, United States

B0-inhomogeneity-insensitive GABA editing with MM suppression has been developed using improved MEGA-SPECIAL sequence using highly selective (30 ms) editing pulses allowed by 1D ISIS localization and 1D echo planar gradient in the logical S/I direction. MM suppressed GABA editing was successfully achieved in occipital lobe. However, GABA editing in regions near sinuses, e.g. anterior cingulate cortex (ACC), was compromised from imperfect subtraction in the ISIS localization. To reduce artifact in this region, the ISIS and 1D EP gradient were applied in the logical R/L direction together with a 16-step phase-cycled acquisition. These methods significantly improved edited spectra obtained from ACC.

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