Abstract #3978

Increased Rostral Anterior Cingulate Cortex GABA+ Concentrations in IBS Patients with Anxiety

Sofie Tapper^1,2, Adriane Icenhour^2,3, Olga Bednarska³, Anders Tisell^1,2, Susanna Walter^2,3, and Peter Lundberg^1,2

¹Department of Radiation Physics, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, ³Institute of Clinical and Experimental Medicine, Division of Gastroenterology, Linköping University, Linköping, Sweden

The aim was to investigate whether Glutamate and GABA concentrations were altered in the rACC in patients with IBS compared to healthy controls, and to investigate if the GABA and Glutamate concentrations were associated with the level of anxiety in IBS patients. We observed higher rACC GABA+ concentrations in IBS patients, whereas Glx concentrations remained unaltered. Moreover, the changes in GABA concentrations were most pronounced in patients with high severity of anxiety. Thus, our findings provide first evidence of dysregulated rACC GABAergic neurotransmission in IBS, and suggest that altered inhibitory neurotransmission may be linked to comorbid anxiety in IBS patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.