Abstract #3977

Feasibility of ultra-short TE MRS with full intensity to detect human brain glutathione, glutamine and GABA on 3 T and 4 T

Xi Chen¹, Yihong Yang², Dost Ongur¹, and Fei Du¹

¹McLean Hospital; Harvard Medical School, Belmont, MA, United States, ²National Institute on Drug Abuse, Baltimore, MD, United States

GABA, glutamine (Gln) and Glutathione (GSH) are important metabolites in human brain. However, with regular proton MRS, all of them are subject to J modulations during the moderate TE and hardly reliably observed. This study utilizes SPECIAL, an ultra-short TE MRS with full intensity, on 3T and 4T human scanners to test its feasibility to detect GABA, Gln and GSH. Compared to 3T PRESS, SPECIAL on 3T and 4T observed consistent Gln and GSH concentrations with higher reliabilities. Uniquely, 4T SPECIAL observed GABA+MM signal with significantly lower CRLB compared to 3 T measurements.

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