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Abstract #3984

23NA-MRI of the skeletal muscle and skin in patients with adrenal insufficiency

Andreas Max Weng1, Stephanie Burger-Stritt2, Irina-Oana Chifu2, Martin Christa3, Bernhard Petritsch1, Thorsten Alexander Bley1, Herbert Köstler1, and Stefanie Hahner2

1Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 2Department of Medicine I, University Hospital Würzburg, Würzburg, Germany, 3Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany

Patients with chronic primary adrenal insufficiency require life-long glucocorticoid- and mineralocorticoid- replacement therapy. Monitoring of treatment is mainly based on clinical parameters and additional measurement of electrolyte status and plasma renin levels. However, obtained values often do not correspond to the patients’ subjective well-being and thus may not fully reflect optimal treatment. The present study investigated sodium content in the calf muscle and the skin obtained via 23Na-MRI in patients with chronic primary AI and healthy controls. Sodium content assessed by 23Na-MRI correlates with further parameters of mineralocorticoid activity and may serve as an objective method to monitor hormone substitution therapy in patients with adrenal insufficiency.

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