Abstract #3984

23NA-MRI of the skeletal muscle and skin in patients with adrenal insufficiency

Andreas Max Weng¹, Stephanie Burger-Stritt², Irina-Oana Chifu², Martin Christa³, Bernhard Petritsch¹, Thorsten Alexander Bley¹, Herbert Köstler¹, and Stefanie Hahner²

¹Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ²Department of Medicine I, University Hospital Würzburg, Würzburg, Germany, ³Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany

Patients with chronic primary adrenal insufficiency require life-long glucocorticoid- and mineralocorticoid- replacement therapy. Monitoring of treatment is mainly based on clinical parameters and additional measurement of electrolyte status and plasma renin levels. However, obtained values often do not correspond to the patients’ subjective well-being and thus may not fully reflect optimal treatment. The present study investigated sodium content in the calf muscle and the skin obtained via ²³Na-MRI in patients with chronic primary AI and healthy controls. Sodium content assessed by ²³Na-MRI correlates with further parameters of mineralocorticoid activity and may serve as an objective method to monitor hormone substitution therapy in patients with adrenal insufficiency.

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