Meeting Banner
Abstract #3985

Electrophysiological stimulation of excised rat muscle elicits a measurable change in tissue sodium concentration using 23Na-MRI

Frank Riemer1, Joshua Kaggie1, Cormac O'Neill2, Mary McLean3, James Grist1, Myfanwy Hill3, Joe Guy3, Rolf Schulte4, Martin Graves1,2, James Fraser5, and Ferdia Gallagher1

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 3Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 4GE Healthcare, Munich, Germany, 5Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

Changes in the tissue sodium gradient play an important role in cell signalling such as at the neuromuscular junction and as part of neuronal action potentials. 23Na-MRI has the ability to measure the macroscopic sodium distribution. In this study we investigated the changes in tissue sodium in an electrically stimulated and freshly excised rat leg muscle.

This abstract and the presentation materials are available to members only; a login is required.

Join Here