Abstract #3985

Electrophysiological stimulation of excised rat muscle elicits a measurable change in tissue sodium concentration using 23Na-MRI

Frank Riemer¹, Joshua Kaggie¹, Cormac O'Neill², Mary McLean³, James Grist¹, Myfanwy Hill³, Joe Guy³, Rolf Schulte⁴, Martin Graves^1,2, James Fraser⁵, and Ferdia Gallagher¹

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ³Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ⁴GE Healthcare, Munich, Germany, ⁵Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

Changes in the tissue sodium gradient play an important role in cell signalling such as at the neuromuscular junction and as part of neuronal action potentials. ²³Na-MRI has the ability to measure the macroscopic sodium distribution. In this study we investigated the changes in tissue sodium in an electrically stimulated and freshly excised rat leg muscle.

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