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Abstract #3988

31P MRS of the frontal lobe of human brain at 7T

Shizhe Steve Li1, Li An1, Jan Willem van der Veen1, Maria Ferraris Araneta1, Johnson Christopher1, Yu Shao2, Shumin Wang1, Jun Shen1, and Jun Shen1

1National Institutes of Health, Bethesda, MD, United States, 2Chongqing University of Posts and Telecommunications, Chongqing, China

The majority of neuropsychiatric disorders are thought to be originated in the frontal lobe. Increasing the SNR of frontal lobe 31P MRS using a surface coil can be very important because many MRS manifestations of psychiatric illnesses could be subtle. This study demonstrates the feasibility of high SNR 31P MRS of human frontal lobe using a surface coil and 3D CSI at 7 Tesla. Comparing to the occipital lobe spectra acquired from the same subject it was shown that the sensitivity and spectral resolution of 31P MRS spectra of the frontal lobe can be made comparable to that of the occipital lobe.

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