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Abstract #3990

Unambiguous detection of cardiac Pi using long TM 31P STEAM

Albrecht Ingo Schmid1,2, Ladislav Valkovic1,3, Elizabeth M Tunnicliffe1, and Christopher T Rodgers1,4

1OCMR, RDM Cardiov. Medicine, University of Oxford, Oxford, United Kingdom, 2CMPBME, MR Physics, MRCE, Medical University of Vienna, Vienna, Austria, 3Institute of Measurement Sciences, Department of Imaging Methods, Slovak Academy of Science, Bratislava, Slovakia, 4Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Inorganic Phosphate is a resonance that holds important information on the metabolic state of tissues. From its resonance frequency, intracellular pH can be derived. The ratio of Pi to PCr or ATP are also important markers. Unlike in other tissues, myocardial Pi is frequently hidden underneath blood 2,3-DPG signals. Using 7 T STEAM's TM delay to be one cardiac cycle, blood-pool originating signals are gone and the Pi resonance is clearly visible. In 3 subjects, Pi signal was detected and quantified. The signal was around 4.89±0.02ppm, corresponding to a pH of 7.08±0.02. This is a breakthrough for the investigation of cardiac metabolism.

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