Abstract #3990

Unambiguous detection of cardiac Pi using long TM 31P STEAM

Albrecht Ingo Schmid^1,2, Ladislav Valkovic^1,3, Elizabeth M Tunnicliffe¹, and Christopher T Rodgers^1,4

¹OCMR, RDM Cardiov. Medicine, University of Oxford, Oxford, United Kingdom, ²CMPBME, MR Physics, MRCE, Medical University of Vienna, Vienna, Austria, ³Institute of Measurement Sciences, Department of Imaging Methods, Slovak Academy of Science, Bratislava, Slovakia, ⁴Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Inorganic Phosphate is a resonance that holds important information on the metabolic state of tissues. From its resonance frequency, intracellular pH can be derived. The ratio of P_i to PCr or ATP are also important markers. Unlike in other tissues, myocardial P_i is frequently hidden underneath blood 2,3-DPG signals. Using 7 T STEAM's T_M delay to be one cardiac cycle, blood-pool originating signals are gone and the Pi resonance is clearly visible. In 3 subjects, P_i signal was detected and quantified. The signal was around 4.89±0.02ppm, corresponding to a pH of 7.08±0.02. This is a breakthrough for the investigation of cardiac metabolism.

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