Abstract #3995

Quantification of human cardiac inorganic phosphate content in vivo by 31P-MRSI at 7T

Ladislav Valkovic^1,2, Albrecht I Schmid^1,3, Lucian AB Purvis¹, Jane Ellis¹, Matthew D Robson¹, Stefan Neubauer¹, and Christopher T Rodgers^1,4

¹Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sceinces, Bratislava, Slovakia, ³High-Field MR Centre, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁴The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

Determination of human cardiac Pi using ³¹P-MRS is challenging as the resonance frequency of Pi is concealed by a close resonating 2,3-DPG signal originating from blood. Long TR acquisition using adiabatic excitation at 7T can compensate for the rapid blood signal replacement in partially-saturated short TR scans. In order to quantify Pi concentration in vivo, knowledge about longitudinal relaxation of Pi is still required. We have measured the T₁ of Pi in 4 healthy volunteers at 7T using dual-TR method and used this value to quantify cardiac Pi concentration in 8 healthy volunteers.

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