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Abstract #3995

Quantification of human cardiac inorganic phosphate content in vivo by 31P-MRSI at 7T

Ladislav Valkovic1,2, Albrecht I Schmid1,3, Lucian AB Purvis1, Jane Ellis1, Matthew D Robson1, Stefan Neubauer1, and Christopher T Rodgers1,4

1Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sceinces, Bratislava, Slovakia, 3High-Field MR Centre, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 4The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

Determination of human cardiac Pi using 31P-MRS is challenging as the resonance frequency of Pi is concealed by a close resonating 2,3-DPG signal originating from blood. Long TR acquisition using adiabatic excitation at 7T can compensate for the rapid blood signal replacement in partially-saturated short TR scans. In order to quantify Pi concentration in vivo, knowledge about longitudinal relaxation of Pi is still required. We have measured the T1 of Pi in 4 healthy volunteers at 7T using dual-TR method and used this value to quantify cardiac Pi concentration in 8 healthy volunteers.

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