Abstract #3996

In Vivo Measurement of Cerebral NAD Contends and Redox State in Young Mouse.

Radek Skupienski^1,2,3, Kim Q Do¹, Roger Marti³, and Lijing Xin²

¹Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Prilly, Switzerland, ²Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Chemistry, HEIA-FR, Fribourg, Switzerland

Nicotimamide adenine dinucleotide (NAD⁺ and NADH) is a key player of cell energy metabolism. ³¹P-MRS has been demonstrated for in vivo measurement of NAD content and redox state in cat and human brain, however, there is no reports in mouse brain. In this study we established the in vivo measurement of NAD⁺, NADH and NAD⁺/NADH in young (prepubetrtal) mice and compared two different quantification methods (Least square fitting and LCmodel). This study demonstrated the feasibility of in vivo measurement of NAD⁺, NADH and redox state in mouse brain and it opens the prospect of studying longitudinally the energy metabolism and redox dysfunction in mouse models of brain pathologies.

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