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Abstract #3998

Dietary modulation of metabolic enzyme activity assessed by dynamic in vivo 31P-MRS of hepatic fructose metabolism

Christian T. Farrar1, Gregory Tesz2, and Jeremy Wellen2

1Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Pfizer Worldwide Research & Development, Cambridge, MA, United States

In this study, 31P-MRS was applied to monitor hepatic fructose metabolism of rats in response to IV fructose challenge. Animals exposed to 7-days of sucrose-enriched diet experienced enhanced fructose clearance relative to animals on an isocaloric control diet. The finding of more efficient fructose metabolism in the sucrose fed group corresponded with elevated KHK and AldoB gene expression, two key enzymes responsible for fructose clearance. Treatment of animals on sucrose diet with a KHK inhibitor nearly completely blocked fructose metabolism and prevented increased expression of these enzymes, implying that metabolism of fructose elicits the enzyme induction rather than fructose itself.

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