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Abstract #3999

In vivo  $$$^{31}\hspace{0.1 mm}$$$P-MRS of triple negative breast cancer patients

Erwin Krikken1, Wybe J.M. van der Kemp1, Peter R. Luijten1, Kenneth G.A. Gilhuijs2, Dennis W.J. Klomp1, Hanneke W.M. van Laarhoven3, and Jannie P. Wijnen1

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Image Science Institute, UMC Utrecht, Utrecht, Netherlands, 3Medical Oncology, Academic Medical Centre Amsterdam, Amsterdam, Netherlands

31P-MR spectra of breast cancer tissue have shown very high GPC/PC ratios in xenografts for triple negative (TN) tumors. We set out to investigate if this is also visible in vivo in six TN breast cancer patients. In two of the patients the phosphocholine (PC) peak is missing or approaching zero. To the best of our knowledge, this is the first time that this phenomenon is shown in vivo in breast cancer patients, however, the relation of the presence or absence of PC and TN subtype remains to be investigated.

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