Abstract #3999

In vivo $$$^{31}\hspace{0.1 mm}$$$P-MRS of triple negative breast cancer patients

Erwin Krikken¹, Wybe J.M. van der Kemp¹, Peter R. Luijten¹, Kenneth G.A. Gilhuijs², Dennis W.J. Klomp¹, Hanneke W.M. van Laarhoven³, and Jannie P. Wijnen¹

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Image Science Institute, UMC Utrecht, Utrecht, Netherlands, ³Medical Oncology, Academic Medical Centre Amsterdam, Amsterdam, Netherlands

³¹P-MR spectra of breast cancer tissue have shown very high GPC/PC ratios in xenografts for triple negative (TN) tumors. We set out to investigate if this is also visible in vivo in six TN breast cancer patients. In two of the patients the phosphocholine (PC) peak is missing or approaching zero. To the best of our knowledge, this is the first time that this phenomenon is shown in vivo in breast cancer patients, however, the relation of the presence or absence of PC and TN subtype remains to be investigated.

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