Abstract #4000

Detection of 13C glucose metabolism in multiple human brain regions using dynamic 1H MRS

Steven Zhang¹, Chathura Kumaragamage², Pedro Rosa Neto³, and Jamie Near^1,2,4

¹Integrative Program of Neuroscience, McGill University, Montreal, QC, Canada, ²Biomedical Engineering, McGill University, Montreal, QC, Canada, ³Neurology & Neurosurgery, Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Magnetic Resonance Imaging, Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada

In vivo carbon-13 magnetic resonance spectroscopy is a quantitative technique for studying brain metabolism. Here, we demonstrate the use of ¹H MRS to indirectly observe the metabolism of ¹³C labelled glucose, simultaneously in two brain regions in a single healthy volunteer. This was done using only standard proton (¹H) MRS sequences and hardware. Our results demonstrate an accumulation of ¹³C label in glutamate and glutamine that is distinctly observable due to the pronounced effect of heteronuclear scalar coupling. This technique provides insight into neuronal metabolic rates and may provide complimentary information to ¹⁸F-FDG PET in the study of neurodegenerative disorders.

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