Abstract #4007

Metabolic Profiling of Blood Plasma for Distinguishing Prostate Cancer in Patients with Positive Biopsy and Negative Biopsy using NMR Spectroscopy

Naranamangalam R Jagannathan¹, Pradeep Kumar¹, Rajeev Kumar², Virendra Kumar¹, Senthil S Kumaran¹, Sanjay Thulkar³, Sanajy Sharma³, and Siddhartha D Gupta⁴

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Urology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, ⁴Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

The metabolic profiling of blood plasma sample for distinguishing prostate cancer (PCa) patients with positive biopsy (n=32) and negative biopsy (n=30) using NMR spectroscopy was investigated. A significantly higher concentration of lactate, choline, glucose and a lower concentration of histidine, tyrosine and phenylalanine were observed in blood plasma of PCa patients with positive biopsy as compared to negative biopsy. Our results suggest alterations in amino acid, energy, glucose and choline metabolisms, which may have association with disease progression.

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