The present study demonstrated the metabolic profile of urine samples of prostate cancer (PCa) patients (n=33) and healthy controls (HC; n=21) using 700 MHz high-resolution proton NMR for early diagnosis and to define noninvasive biomarker/s. A significantly lower concentration of leucine, histidine, tyrosine, citrate, dimethylglycine, glycerophosphocholine, choline, creatinine, indoxyl sulphate and formate was seen in PCa patients. These findings suggest metabolic alterations due to mitochondrial dysfunction, cell proliferation, energy demand, oxidative stress and protein turnover in PCa patients.
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