There is a necessity for novel and quick drug response screening methods for providing lead information for drug discovery. In this context, NMR can be a potential screening method. This study has used proton NMR spectroscopy for drug response in HIV-1 psuedovirus infected TZM-bl cells after treatment with TAK 779 (positive control), and benzene extracts of Terminalia bellerica and Zingiber officinale. Significant reduction in metabolites was observed in infected cells and metabolites were subsequently restored closer to normal levels on treatment with positive control and plant extracts. The study has demonstrated NMR to be a quick screening method for drug response.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords