Abstract #4011

Comparative NMR urine metabolomics of whole body or partial body radiation exposure: Stepping towards delivery of potent marker for radiation exposure

Poonam Rana¹, Ajaswrata Dutta², Sushant K Mishra¹, Kiran Maan¹, Manju Lata Gupta², and Subash Khushu¹

¹NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India, ²Division of Radioprotective Drug Development Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Stepping forward towards the quest of high throughput radiation marker, the present study looks for a common signature on comparison of NMR based urine metabolomics post whole body or partial irradiation. Different group of animals were exposed to 10 Gy whole body or partial radiation. Irradiated group were clustered apart from controls; showed similar pattern on radiation exposure irrespective of whole body or cranial and identified taurine, citrate as common metabolites in whole body and partial radiation groups. The similar pattern observed post partial or whole body irradiation further confirm these metabolites as potent markers for radiation exposure.

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