Meeting Banner
Abstract #4015

Determination of the metabolome of Giardia lamblia by 1H Magic Angle Spinning NMR

Martina Vermathen1, Joachim Müller2, Norbert Müller2, and Peter Vermathen3

1Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland, 2Institute of Parasitology, University of Bern, Bern, Switzerland, 3epartments for BioMedical Research and Radiology, University of Bern, Bern, Switzerland

The intestinal protozoan parasite Giardia lamblia is a major cause of persistent diarrhea in humans and animals worldwide. Details concerning underlying metabolic pathways in Giardia are scarce and a methodology to study giardial intermediary and energy metabolism is required. Here, a high resolution magic angle spinning (HR-MAS) NMR study is presented determining the metabolic profile of G. lamblia trophozoites. This study builds the basis of following investigations on Giardia that are resistant against Metronidazole and other nitro compounds, which have been used since decades as therapy of choice against giardiasis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here