There is an urgent need to develop novel therapeutic strategies for malignant brain tumors. Purposes of this study were: 1) to investigate in glioma cells the alterations induced by metformin in the levels of metabolites produced by different biochemical pathways ( glycolysis and phosphatidylcholine (PC) metabolism); 2) to evaluate the possibility to enhance the antiproliferative effects of metformin by a combination of metformin with a selected inhibitor of PC metabolism. We found : a) activation of PC-plc and PCho accumulation in metformin-treated cells; b) enhanced cell death in glioma cells with a combination of metformin and the PC-plc.
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