Meeting Banner
Abstract #4047

Feasibility of MR guided High Intensity Focused Ultrasound (MRgHIFU) for treating recurrent gynecological tumours: a pilot study

Sharon L Giles1,2, Ian Rivens3, Katja De Paepe1, Veronica A Morgan2, Georgios Imseeh4, Gail R ter Haar3, Alexandra Taylor4, and Nandita M deSouza1

1CRUK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom, 2CRUK Cancer Imaging Centre, Royal Marsden Hospital, London, United Kingdom, 3Therapeutic Ultrasound, Institute of Cancer Research, London, United Kingdom, 4Gynae-Oncology, Royal Marsden Hospital, London, United Kingdom

MR guided high intensity focused ultrasound (MRgHIFU) treatment plans were generated for 16 patients with recurrent gynecological tumors. Treatment volumes (i) ignoring risk to non-target regions (TVunconstrained), (ii) considering risk, assuming that patients were optimally prepared (TVoptimal), and (iii) assuming no preparation was possible (TVno-prep), were compared with planning target volume (PTV). 9/16 patients (56%) with tumor volumes ≤53 ml were considered feasible to treat safely if optimally prepared (TVoptimal≥50% PTV). Main limiting factors were transducer focal range, bone in the beam path, and risk to bowel. However, even without preparation, 4/16 patients (25%) remained feasible to treat (TVno-prep ≥50% PTV).

This abstract and the presentation materials are available to members only; a login is required.

Join Here