Abstract #4047

Feasibility of MR guided High Intensity Focused Ultrasound (MRgHIFU) for treating recurrent gynecological tumours: a pilot study

Sharon L Giles^1,2, Ian Rivens³, Katja De Paepe¹, Veronica A Morgan², Georgios Imseeh⁴, Gail R ter Haar³, Alexandra Taylor⁴, and Nandita M deSouza¹

¹CRUK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom, ²CRUK Cancer Imaging Centre, Royal Marsden Hospital, London, United Kingdom, ³Therapeutic Ultrasound, Institute of Cancer Research, London, United Kingdom, ⁴Gynae-Oncology, Royal Marsden Hospital, London, United Kingdom

MR guided high intensity focused ultrasound (MRgHIFU) treatment plans were generated for 16 patients with recurrent gynecological tumors. Treatment volumes (i) ignoring risk to non-target regions (TV_{unconstrained}), (ii) considering risk, assuming that patients were optimally prepared (TV_optimal), and (iii) assuming no preparation was possible (TV_no-prep), were compared with planning target volume (PTV). 9/16 patients (56%) with tumor volumes ≤53 ml were considered feasible to treat safely if optimally prepared (TV_optimal≥50% PTV). Main limiting factors were transducer focal range, bone in the beam path, and risk to bowel. However, even without preparation, 4/16 patients (25%) remained feasible to treat (TV_no-prep ≥50% PTV).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.