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Abstract #4051

Model Predictive control of MRI-guided HIFU for Hyperthermia

Lukas Christian Sebeke1, Xi Luo2, Bram de Jager2, Edwin Heijman3, WMPH Heemels2, and Holger GrĂ¼ll1

1Radiology, University Clinic of Cologne, Cologne, Germany, 2Eindhoven University of Technology, Eindhoven, Netherlands, 3Philips Research Germany, Cologne, Germany

Hyperthermia has been shown in clinical trials to strongly enhance therapeutic efficacy of radio- and chemotherapy. The main challenge in hyperthermia is to achieve spatially homogenous temperatures between about 41-43 oC for ca. one hour. Magnetic Resonance Imaging-guided High Intensity Focussed Ultrasound (MR-HIFU) enables heating of tissues with high spatial accuracy. We developed a new regulatory algorithm based on Model Predictive Control (MPC) for stable MR-HIFU-hyperthermia, which is designed to find effective heating patterns based on predictions of the temperature evolution in tissue. A comparison with the currently available controller is presented, detailing advantages, shortcomings and opportunities.

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